Bastien presented a poster and an appetizer talk on “Rearrangement-based total syntheses of oxacyclic natural products“, featuring most of our achievements on this topic during the last four years, i.e. 5 total syntheses and 3 synthetic methodologies.

Bruce Lockett-Walters, Simon Thuillier, Emmanuel Baudouin, Bastien Nay: A concise total synthesis of phytotoxic radulanin A facilitated by the photochemical ring expansion of a 2,2-dimethylchromene in flow. Available on ChemRXiv at

Many thanks to my dear colleagues at ICMMO/Université Paris-Saclay at Orsay for the invitation to give a lecture and the excellent discussions we had on 19th April 2022: Making compounds inspired by Nature: from total synthesis to medicinal chemistry

Dear colleagues, I cordially invite you to submit your most exciting, original research to be published in the Thematic Issue “Total synthesis: an enabling science” in the non-profit, peer-reviewed Beilstein Journal of Organic Chemistry (BJOC). This thematic issue welcomes articles dealing with total synthesis. Total synthesis is the science of constructing molecules, often complex and […]

RECOB is the French meeting of biological organic chemistry, taking place at Aussois in the Alps every two years. Bastien presented a lecture on 23th March: Making compounds inspired by Nature: from total synthesis to medicinal chemistry

Antoine Gamet comes from ECPM Strasbourg and joined us to perform a six-month internship to complete his M2 year. He is working on the total synthesis of a natural product inhibiting actin polymerization. We thank the Labex CHARM3AT for funding the fellowship.

Alexis Paquin is a student from Université du Québec à Trois-Rivières. He holds a Master degree and will perform an internship for three months. He is working on the total synthesis of quinazoline alkaloids. We thank the Mitacs for the fellowship.

He spoke about quinoline C-H functionnalization, strategies for the generation of compound libraries, total synthesis and oxepin ring construction. He is now a doctor of Institut Polytechnique de Paris! Thanks to Joanna Wencel-Delord, Geoffroy Sorin, Laurence Grimaud and Philippe Dauban for the fruitful discussions.

Quentin Ronzon Synthesis of natural and Nature-inspired heterocyclic compounds: quinolone library and oxepin-containing cyclotripeptides Thèse de doctorat de l’Institut Polytechnique de Paris préparée à l’Ecole PolytechniqueÉcole doctorale n°626 de l’Institut Polytechnique de Paris (ED IP Paris)Spécialité de doctorat: Chimie Graphical abstract

“The rapid emergence of antibiotic resistance (AMR) in bacteria is one of the most pressing global health threats. Despite its significance, the potential impact of this phenomenon remains largely underappreciated by a large portion of the population. The recent Covid-19 pandemic has further intensified the use of antibiotics, often without clinical justification, which is expected […]