Our research projects deal with the total synthesis of natural products, tinged with methodological developments, chemical biology, medicinal chemistry, natural product chemistry and natural history topics. Bio-inspired strategies take a particular place in our approaches. Another recent aspect of our research concern the synthesis of chemical probes for structural biology purposes. Utility and biological interfaces are some of our motivations to synthesize compounds at Ecole Polytechnique. Our group is part of the Laboratoire de Synthèse Organique (LSO).